Recombinant Human TGF-β2

General description

Transforming Growth Factor Beta 2 (TGF-β2) is a secreted cytokine involved in embryonic development, tissue morphogenesis, and immune modulation. It exhibits distinct biological activities from TGF-β1 in neural and ocular systems. Recombinant Human TGF-β2 Protein (Y07801N) is expressed from mammalian cells. It contains AA Ala 303 - Ser 414 (Accession # P61812), and is widely used in advanced cell culture, developmental biology, and ophthalmology research.

Application

· Neural Stem Cell Differentiation — Promotes neuronal and glial lineage specification.

· Ocular Tissue Engineering — Supports corneal endothelial and retinal pigment epithelium culture.

· Chondrogenic Differentiation — Drives cartilage matrix formation in MSC-based tissue engineering.

· Immune Modulation Studies — Investigate context-dependent immunosuppressive mechanisms.

· Serum-Free Culture Systems — Suitable for chemically defined and xeno-free cell culture media.

Product Specifications

Stability and Reconstitution

· 36 months at -20°C to -80°C in lyophilized state;

· 6 months at -20°C to -80°C under sterile conditions after reconstitution;

· 7-10 days at 2°C to 8°C under sterile conditions after reconstitution;

· Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

· It is recommended to redissolve in 4 mM HCL.

Backgroud

Transforming Growth Factor Beta 2 (TGF-β2), also known as G-TSF or cetermin, is a member of the TGF-β superfamily. TGF-β2 shares approximately 70% sequence homology with TGF-β1 but exhibits unique expression patterns and receptor-binding affinities. It is the predominant TGF-β isoform in neural and ocular tissues and plays critical roles in blood-brain barrier maintenance, lens epithelial cell behavior, and palatal fusion during embryogenesis. TGF-β2 signals through the same receptor complex as TGF-β1 but can elicit distinct cellular responses depending on cellular context and co-receptor expression.

Q&A

Q1: What is TGF-β2 mainly used for?

TGF-β2 is primarily used for neural differentiation, ocular tissue culture, chondrogenesis, and developmental biology research.

Q2: Is this TGF-β2 suitable for serum-free culture systems?

Yes. EastMabBio recombinant TGF-β2 is compatible with serum-free, xeno-free, and chemically defined media systems.

Q3: How should recombinant TGF-β2 be stored?

Lyophilized protein should be stored at -20°C or below. After reconstitution, aliquot and avoid repeated freeze-thaw cycles.

Q4: What shipping conditions are used?

Products are shipped on dry ice with validated cold-chain packaging to maintain stability during international transportation.

Q5: Do you provide QC documents?

Yes. COA, MSDS, TSE-BSE statements, endotoxin reports, bioactivity data, and additional QC documentation are available upon request.