Recombinant Human Neurturin Instruction

General Description

Neurturin is a GDNF family ligand that promotes the survival of sympathetic, parasympathetic, and enteric neurons. It signals through GFRα2 and RET receptors with distinct tissue distribution from GDNF. Recombinant Human Neurturin Protein (Y08401H) is expressed from mammalian cells. It contains AA Ala 96 - Arg 197 (Accession # Q99748), and is widely used in advanced cell culture, neuroscience research, and autonomic nervous system studies.

Application

· Sympathetic and Parasympathetic Neuron Culture — Supports the survival and differentiation of autonomic neurons.

· Enteric Nervous System Development — Promotes the development and maintenance of gut-innervating neurons.

· Retinal Photoreceptor Protection — Models neuroprotective effects in retinal degeneration.

· Autonomic Neuropathy Research — Investigates Neurturin-mediated protection in diabetic and toxic neuropathy models.

· Serum-Free Culture Systems — Suitable for chemically defined and xeno-free cell culture media.

Product Specifications

Stability and Reconstitution

36 months at -20°C to -80°C in lyophilized state;

6 months at -20°C to -80°C under sterile conditions after reconstitution;

7-10 days at 2°C to 8°C under sterile conditions after reconstitution;

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

It is recommended to redissolve in sterile deionized water.

Backgroud

Neurturin is a member of the GDNF family ligands that signals through the GFRα2 co-receptor and RET tyrosine kinase. It was originally identified based on its ability to support sympathetic neuron survival and exhibits distinct expression patterns and receptor specificity from GDNF. Neurturin is particularly important for the development and maintenance of the autonomic nervous system, including sympathetic ganglia, parasympathetic terminals, and the enteric nervous system. In the retina, Neurturin supports photoreceptor survival and has been explored for therapeutic applications in retinitis pigmentosa and age-related macular degeneration.

Q&A

Q1: What is Neurturin mainly used for?

Neurturin is primarily used for autonomic neuron culture, enteric nervous system development, retinal protection, and neuropathy research.

Q2: Is this Neurturin suitable for serum-free culture systems?

Yes. EastMabBio recombinant Neurturin is compatible with serum-free, xeno-free, and chemically defined media systems.

Q3: How should recombinant Neurturin be stored?

Lyophilized protein should be stored at -20°C or below. After reconstitution, aliquot and avoid repeated freeze-thaw cycles.

Q4: What shipping conditions are used?

Products are shipped on dry ice with validated cold-chain packaging to maintain stability during international transportation.

Q5: Do you provide QC documents?

Yes. COA, MSDS, TSE-BSE statements, endotoxin reports, bioactivity data, and additional QC documentation are available upon request.