- Cat.No: C02601
Cat.No .: | C02601 |
Source: | Monoclonal Mouse Antibody |
Subtype: | mIgG1/mK |
Molecular Mass: | 150 kDa |
Expression Host: | HEK293 cells |
Formulation: | Purified, Liquid |
Buffer: | Phosphate Buffered Saline,5%mannital,0.05% Tween20, pH7.4 |
Purification: | >95% pure (SDS-PAGE). |
Storage: | For long term storage, the product should be stored at -20°C or lower. |
Please avoid repeated freeze-thaw cycles.
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Description:
Rotavirus, member Reoviridae family, is a non-enveloped double-stranded RNA (dsRNA) virus whose architecture is that three concentric capsids surround a genome of 11 segments of dsRNA. The RNA encodes six structural proteins (VP1, VP2, VP3, VP4, VP6 and VP7) and six non-structural proteins (NSP1, NSP2, NSP3, NSP4, NSP5 and NSP6), both determining the host specificity, cell entry and enzymatic functions and comprising epitopes that generate immune responses. The non-structural proteins are associated with genome replication. Two rotavirus vaccines are broadly used worldwide: the RV5 vaccine and the RV1 vaccine. RV5 vaccine is a live attenuated pentavalent vaccine,while the RV1 vaccine is a live attenuated human monovalent virus vaccine.
Figure.1 Rotavirus Structure Diagram
Figure.2 Rotavirus replication cycle
References:
[1] Crawford SE, et al. 2017. Nat Rev Dis Primers. 3:17083.
[2] Mahmud-Al-Rafat A, et al. 2018. Infection. 46(1: 15-24.