- Cat.No: Y02101
Product Information：
Known as: | Interleukin 3, Hematopoietic Growth Factor, Multipotential Colony-Stimulating Factor, P-Cell Stimulating Factor, Mast-Cell Growth Factor, MULTI-CSF, MCGF |
Source： | Homo sapiens (Human) |
Cat.No.: | Y02101 |
Expression Host： | HEK293 cells |
Formulation：
Lyophilized from 0.22 μm filtered solution in PBS，5%mannital，0.01% Tween80 pH7.4.
Quality Control：
Purity: ≥ 95% as determined by reducing SDS-PAGE.
Endotoxin: ＜ 0.5 EU/mg as determined by LAL test.
Storage：
Use a manual defrost freezer and avoid repeated freeze - thaw cycles.
12 months from date of receipt, -20 to -70℃ as supplied.
1 month, 2 to 8℃ under sterile conditions after reconstitution.
6 months, -20 to -70℃ under sterile conditions after reconstitution.
FOR RESEARCH USE ONLY
Description：
This protein is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]
Interleukin-3 (IL-3) is a member of the beta common (βc) cytokine family, which also includes granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-5. The βc family regulates multiple biological processes such as native and adaptive immunity, inflammation, normal and malignant hemopoieis, and autoimmunity. IL-3 is a cytokine with multiple biologic functions, mainly produced by activated T-lymphocytes and mast cells, with an important regulatory activity on the generation of hematopoietic and immune cells.
This group of cytokines signals through the activation of heterodimeric cell surface receptors, composed by a cytokine-specific α chain and the shared βc subunit. These cytokines signal through the βc subunit: The activation of IL-3R is thought to involve the sequential assembly of a receptor complex, with an initial step represented by the binding of IL-3 to IL-3Rα (also known as CD123), followed by a second step represented by the recruitment of βc subunit and assembly of a receptorial complex, bringing JAK2 molecule together to trigger downstream signaling.
Figure Signaling pathways derived from activated IL-3/GM-CSF/IL-5 receptor complexes
References：
[1] Testa U, et al. 2019. Cancers (Basel). 11(9):1358.
[2] Hercus TR, et al. 2013. Cytokine Growth Factor Rev. 24(3):189-201.